Neurofibroma

General: Sporadic and solitary or multiple, or multiple "classically" in the setting of neurofibromatosis type 1. Sporadic etiology typically affects 20-40 year olds, but they may appear at a much younger age in neurofibromatosis. There are multiple variants, some of more significance.

Gross: Fusiform, rubbery, grey and glistening.

Microscopic: Arise within a nerve, but often extend beyond epineurium into soft tissue. Typically more cellular centrally, and more edematous peripherally.

Differential Diagnosis:

Stains:

• Positive: S100 in associated Schwann cells, CD34 in endoneurial fibroblasts
• Negative:
• Suggested, focused panel:

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