Carcinoid (tumor, not syndrome) (aka. well-differentiated neuroendocrine carcinoma)

General: A carcinoid tumor may or may not be associated with a clinical carcinoid syndrome, and should be distinguished from other neuroendocrine tumors or carcinomas, which may also be associated with a clinical carcinoid syndrome.

Gross: Usually a well circumscribed mass with an ivory to pink cut surface and no necrosis. Sometimes locally invasive, but rarely metastatic; metastases also tend to be nodular and well circumscribed.

Microscopic: Grows in nests or trabeculae of generally uniform, medium-sized polygonal cells with round to oval, finely granular (salt and pepper) nuclei. May develop rosettes or small acinar structures with or without mucin. Scanty vascular stroma. Minimal or no mitotic activity or necrosis.

Differential Diagnosis: Neuroendocrine tumors of higher grade, ....

Stains:

• Positive: Chromogranin A, synaptophysin, CKC,
• Negative: S100, CK7, CK20,
• Suggested, focused panel:

(PathologyOutlines.com)

Images:


Cases:

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